Increased cervical dysplasia in intravenous cyclophosphamidetreated patients with SLE: a preliminary study
Identifieur interne : 002531 ( Main/Exploration ); précédent : 002530; suivant : 002532Increased cervical dysplasia in intravenous cyclophosphamidetreated patients with SLE: a preliminary study
Auteurs : H. Bateman ; Y. Yazici [États-Unis] ; L. Leff ; M. Peterson ; S A Paget [États-Unis]Source :
- Lupus [ 0961-2033 ] ; 2000-09.
English descriptors
- Teeft :
- Arthritis rheum, Azathioprine, Cervical, Cervical cancer, Cervical dysplasia, Cervical problems, Cyclophosphamide, Data collection, Disease duration, Dysplasia, Erythematosus, Estrogen, Intravenous, Lupus, Lupus nephritis, Malignancy, Median dose, Previous dysplasia, Prospective studies, Rheum, Smear, Special surgery, Study group, Systemic, Systemic lupus erythematosus.
Abstract
To determine if intravenous cyclophosphamide (IV-C) causes an excess of cervical dysplasia and/or cancer in systemic lupus erythematosus (SLE) patients, a retrospective review was conducted. Patients with SLE who received IV-C between 1988–98 (study group) were compared with a group of SLE patients who had not received IV-C (control group). Of the 79 IV-C-treated SLE patients identified, we excluded 18 because of absence of pertinent data. We found 10 cases of cervical dysplasia in the remaining 61 patients, compared to 2 in 49 non-exposed patients (P < 0.04). Comparison of the two groups revealed no difference in: mean years of disease duration, months of follow-up and age. The non-exposed patients were more likely to be on estrogen and hydroxychloroquine but less often on steroids and azathioprine. The study group with and without dysplasia were assessed; we found no difference in the mean, or total IV-C dose, smoking and estrogen use. There was a significant decrease in time to dysplasia in those, given IV-C, with previous dysplasia compared to those without. These preliminary data suggests that IV-C causes an increased number of abnormal Papanicolaou (Pap) smears in SLE patients, particularly those with previous dysplasia.
Url:
DOI: 10.1177/096120330000900711
Affiliations:
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Patients with SLE who received IV-C between 1988–98 (study group) were compared with a group of SLE patients who had not received IV-C (control group). Of the 79 IV-C-treated SLE patients identified, we excluded 18 because of absence of pertinent data. We found 10 cases of cervical dysplasia in the remaining 61 patients, compared to 2 in 49 non-exposed patients (P < 0.04). Comparison of the two groups revealed no difference in: mean years of disease duration, months of follow-up and age. The non-exposed patients were more likely to be on estrogen and hydroxychloroquine but less often on steroids and azathioprine. The study group with and without dysplasia were assessed; we found no difference in the mean, or total IV-C dose, smoking and estrogen use. There was a significant decrease in time to dysplasia in those, given IV-C, with previous dysplasia compared to those without. 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